Overview & Learning Objectives
A range of consolidation treatment options for patients with Philadelphia chromosome (Ph) positive or negative status B-cell acute lymphoblastic leukaemia (B-ALL) are now available in both the adult and paediatric settings.1–3 However, disease outcomes remain suboptimal in some patients including post-consolidation relapses in adults with minimal residual negative disease and poor survival in certain paediatric subgroups, in addition to a need to reduce chemotherapy toxicity.4–7 In this activity, adult and paediatric oncologists discuss current challenges for front-line consolidation treatment in B-ALL and potential novel consolidation treatment strategies underdevelopment.
After watching this activity, participants should be better able to:
- Describe the current recommendations for front-line consolidation treatment based on MRD status in adult and paediatric patients with B-ALL, including potential treatment sequencing
- Discuss current challenges and consensus in frontline B-ALL treatment for Ph+ and Ph- disease
- Outline potential novel front-line consolidation treatment strategies under development for adult and paediatric patients with B-ALL
Faculty & Disclosures
Prof. Carmelo Rizzari
University of Milano-Bicocca, IRCCS San Gerardo dei Tintori, Monza, Italy
Carmelo Rizzari is Professor of Paediatrics and head of the Paediatric Oncology Unit at the University of Milano-Bicocca, Italy, and President of SIOP Europe (the European Society for Paediatric Oncology).
He is a member of the AIEOP National Board (Italian Association for Paediatric Haematology and Oncology), Chairman of the AIEOP Clinical Pharmacology Committee, and a member of the AEIOP committee for first line and relapsed trials for acute lymphoblastic leukaemia. He has also served as the Principal or co-Principal Investigator for numerous academic or industry-sponsored clinical trials of innovative drugs for resistant/relapsed leukaemias and lymphomas, is author of a large number of scientific publications, and is actively involved in international scientific meetings and disease-specific working groups.
Prof. Rizzari discloses: Consultancy fees from Amgen, Clingen, Jazz Pharmaceuticals, and Servier. Grant and research support from Amgen, Clinigen, Jazz Pharmaceuticals, SERB and Servier. Honorarium from Amgen, Clinigen, Jazz Pharmaceuticals and Servier. Speaker’s bureau participant with Amgen, Clinigen, Jazz Pharmaceuticals and Servier.
Prof. Josep-Maria Ribera
Catalan Institute of Oncology, Josep Carreras Research Institute, Barcelona, Spain
Josep-Maria Ribera is Associate Professor of Medicine at the Autonomous University of Barcelona (UAB), Director of the Stem Cell Transplantation Unit at the Hospital Universitari Germans Trias i Pujol (HUGTP) and Head of the Clinical Hematology Department for the Catalan Institute of Oncology (ICO) also at HUGTP.
He is a member of the Steering Committee for acute lymphoblastic leukemia of the European LeukemiaNet and the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL), in addition to teaching post-graduate courses at several higher education institutions in Span. His research focuses on the study of new treatment approaches and prognostic factors in adult ALL and he collaborates. He has authored/co-authored a large number of published clinical papers and book chapters on Haematology, Oncology and Internal Medicine.
Prof. Ribera discloses: Speaker and advisory boards honoraria from Amgen, Ariad, Pfizer and Shire. Clinical trials for Amgen, Ariad and Pfizer. Research support from Amgen.
- Network NCC. Acute Lymphoblastic Leukemia. Version 3.2023. Available at: https://www.nccn.org/professionals/physician_gls/pdf/all.pdf (accessed November 2023). 2023.
- Hoelzer D, Bassan R, Boissel N, et al. ESMO Clinical Practice Guideline interim update on the use of targeted therapy in acute lymphoblastic leukaemia. Ann Oncol 2023.
- Brown P, Inaba H, Annesley C, et al. Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2020; 18:81-112.
- Bassan R, Brüggemann M, Radcliffe HS, et al. A systematic literature review and meta-analysis of minimal residual disease as a prognostic indicator in adult B-cell acute lymphoblastic leukemia. Haematologica 2019; 104:2028-39.
- Abou Dalle I, Jabbour E, Short NJ. Evaluation and management of measurable residual disease in acute lymphoblastic leukemia. Ther Adv Hematol 2020; 11:2040620720910023.
- Jankovic M, Haupt R, Spinetta JJ, et al. Long-term survivors of childhood cancer: cure and care-the Erice Statement (2006) revised after 10 years (2016). J Cancer Surviv 2018; 12:647-50.
- Pieters R, De Lorenzo P, Ancliffe P, et al. Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study. J Clin Oncol 2019; 37:2246-56.