Introducing chlormethine gel
MIDAS (Mechlorethamine Induced Contact Dermatitis Avoidance Study)
Presenting clinical cases with chlormethine gel
Overview & Learning Objectives
Mycosis fungoides (MF) is one of the most common types of cutaneous T-cell lymphoma (CTCL). Topical chlormethine gel has been specifically developed for the treatment of MF and is recommended by EORTC guidelines as one of several first-line therapies for adults with MF. Contact dermatitis is a common side effect of chlormethine gel. Some patients benefit from the addition of triamcinolone to chlormethine gel in order to reduce dermatitis.
This presentation includes four case reports illustrating the need to tailor treatment to the patient. These demonstrate that mild-to-moderate dermatitis may not require treatment suspension but may require emollients, topical steroids or decreased dosing frequency. Severe dermatitis requires treatment suspension or discontinuation. Although some patients may be unable to tolerate the therapy as typically prescribed, partial responses and complete responses are possible in patients with dermatitis reactions.
After watching this activity participants should be better able to:
- Understand current US clinical practice in the management of MF-CTCL
- Understand the optimal use of chlormethine gel in this treatment setting
- Manage contact dermatitis in MF-CTCL patients treated with chlormethine gel
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